VOLUME II, ISSUE 2
Copyright Dr. Deborah Baker-Racine, 2003
Scientists Connect Alzheimer's Disease To Mercury International Academy of Oral Medicine and Toxicology An Organization Dedicated to Evidence Based Health Care P.O. Box 608531, Orlando, FL 32860-8531 T: 407-298-2450 * F: 407-298-3075 * Email: mziff@iaomt.org * Internet: www.iaomt.org
Research conducted at the University of Calgary Faculty of Medicine has demonstrated that trace amounts of mercury can cause the type of damage to nerves that is characteristic of the damage found in Alzheimer's Disease. The level of mercury exposure is consistent with those levels found in humans with mercury/silver amalgam dental fillings. The exposure to mercury caused the formation of "neurofibrillar tangles," which are one of the two diagnostic markers for Alzheimer's Disease. The scientists found that other metals, including aluminum, did not cause the damage Previous research has shown that mercury can cause the formation of the other Alzheimer's Disease diagnostic marker, "amyloid plaques."
The research, published in a peer-reviewed medical journal, is accompanied by a video visual presentation of the effect. Utilizing digital time-lapse photography, this video shows rapid damage to the nerve cells after introduction of minute amounts of mercury. Funding for this video was provided by the International Academy of Oral Medicine and Toxicology (IAOMT).
SPECIAL NOTE: The University of Calgary has placed a copy of the video on their site at:
http://movies.commons.ucalgary.ca/mercury/
To view the video you will need "Quick Time" Player, which can be downloaded from the site if you do not have it.
This video will be available to media contacts (only) through:
Miss Karen Thomas
Media Relations
University of Calgary, Faculty of Medicine
T: 403-220-2945
F: 403-210-8141 Email: thomask@ucalgary.ca
Media Embargo Date: 26 March 2001
Title: "Retrograde Degeneration of Neurite Membrane Structural Integrity of Nerve Growth Cones Following In Vitro Exposure To mercury."
Authors: Leong, CW; Syed, NI; Lorscheider, FL.
Journal: NeuroReport, 12(4):733-737, 2001.
BIOPROBE COMMENT: This study should remove all doubt regarding the role that dental mercury from amalgam fillings plays in the development of Alzheimer's Disease (AD). Although the American Dental Association would like to have you believe otherwise, science has clearly demonstrated that there is a positive correlation between brain mercury levels and the number and surfaces of "mercury/silver" amalgam dental fillings. The mercury levels that caused the devastating damage to nerve cells in the above referenced study were 100 to 1000 times below those found in the brains of people with "mercury/silver" amalgam dental fillings.
In 1997, researchers at the University of Calgary Medical School and the College of Pharmacy at the University of Kentucky clearly demonstrated that exposing rats to the same levels of mercury vapor that can be released from "mercury/silver" amalgam dental fillings caused the mercury to interact with brain tubulin and disassemble microtubules that maintain neurite structure. The identical neurochemical lesion of similar or greater magnitude is evident in Alzheimer brain homogenates from approximately 80% of patients, when compared to human age-matched neurological controls. (Neurotoxicology 1997;18(2):315-324)
In 2000, researchers at the Neurobiology Laboratory, Psychiatric University Hospital in Basel, Switzerland using neuroblastoma cells exposed to mercury demonstrated an increase in production of amyloid protein that makes up the amyloid plaques as well as significantly increasing the phosphorylation of Tau protein. (J Neurochem 2000 Jan;74(1):231- 236)
Studies demonstrating a correlation between amalgam dental fillings and brain mercury levels:
Lakartidningen 1986 Feb 12;83(7):519-522
Swedish Dental Journal 1987;11(5):179-187
Sci Total Environ
1987 Oct;66:263-268
J Prosthet Dent
1987 Dec:58(6):704-707
FASEB J 1989 Dec;3(14):2651-2646
Sci Total Environ
1990 Dec 1;99(1-2):1-22
Sci Total Environ
1993 Sep 30;138(1-3):101-115
J Trace Elem Med Biol 1995 Jul;9(2):82-87
Zentralbl Hyg U:mweltmed 1996 Feb;198(3):275-291
FASEB J 1998 Aug;12(11):971-980
Biometals 1999 Sep;12(3):227-231
This news release was published by Wayne Obie of www.talkinternational.com
e-mail
communications@talkinternational.com
So are we looking at an epidemic of Alzheimer’s in the world…apparently starting earlier and earlier? (Look around at the people you personally know…how many are there and how many did you know of 20 even 10 years ago?? I believe a large part of the increase in neurological diseases (Alzheimer’s, Parkinson’s, MS, etc) is in fact a consequence of mercury toxicity. particularly as it relates to dental amalgam. Science has told us that low dose chronic exposure probably takes anywhere from 25 to 30 odd years to manifest in health phenomena. Think back…it was about that time that people started to get dental insurance left, right and centre as park of an employment package. I am convinced what we see today is a consequence of all of us being marched off to the dentist to have our teeth “done” and those wonderful “silver” fillings placed by the gram in our heads!
DID YOU KNOW????
Lemon Pledge furniture polish contains more actual lemon than Countrytime Lemonaid Mix!!!
XXXXXX
Drinking soft drinks make you thirstier?? Well it should. Water is needed to breakdown the sugar in non-diet soft drinks and the same applies for alcohol. So one drink of either needs at least 1 glass of water to metabolize it!
CARNOSINE..”FOUNTAIN
OF YOUTH” COMPOUND??
Well it looks that way.. Recent studies are showing that carnosine (a dipeptide or two amino acids joined together..one being beta-alanine and the other is histadine) could be a major consideration in the fight against aging and degenerative disease. Normally you make it in your body and it appears mostly in muscle, heart, kidney and brain cells. Hmmmm…interesting..the most critical cells of aging, I would say… In the studies, the longer living animals had more of it in their cells and with aging and time the amount decreases in human muscle by 63% from age 10 to 70. And although science at this time cannot tell us the total picture of why it is there (we know some of its functions..mentioned later)..they can say it is vital to survival and longevity.
The experiments went something like this…
It seems to have started with the work of Drs. Gail McFarland and Robin Holliday at Australia’s Research Organization (CSRIO). They wanted to see the effects of carnosine on cultured human cells. What they did know was the results of decades of research on human cells and the well-defined pattern in the growth, development and aging of them..referred to as the “Hayflick Phenomenon”. Placed in a growth vat with a fluid (medium) rich in essential nutrients, cells from young donors will quickly begin to reproduce, forming colonies, which fill the vat – and then stop reproducing, to prevent starving themselves out. If half of these cells are removed from the container, the remaining cells will begin growing again to fill their environment.
But this process only goes on so far. At each round of division, the cells are aging or becoming “senescent”. The changes are subtle at fires but as time goes on it becomes more and more obvious that something is very wrong with the cells. They lose their shape and begin to vary wildly in size, the fill up with granular material, they stop forming continuous colonies, losing their even, patterned, regular spacing and begin breaking apart, with individual cells drifting off on their own. Senescent cells stop producing the right proteins from their DNA, losing the functions for which they were designed….same process which happens in skin aging and wrinkling. On the whole, the appearance of the cell culture becomes an unhealthy looking texture. Finally, after about 60 divisions, the cells will stop reproducing and slide into a sort of twilight zone..alive, but inactive…simply waiting for death.
Ok…these are the known or given facts of the study. Now here is what happened. They raised lung and skin cells in one of
two standard cell culture mediums. Then
they kept half of the cells in the original medium, and transferred half to the
same medium supplemented with carnosine.
The results were clear, simple and astonishing! The cells in carnosine not only had from
1 to 7 more population doublings..the cells themselves lived up to two thirds
longer than the standard medium cells!
Carnosine treated cells had broken the Hayflick limit and left it in the
dust!
In the whole person it would be like taking someone like Jean Calmet who lived until 122 being the standard and having her sister in the carnosine group, surviving until 200 years old!
This is great..but the best news is that adding carnosine to the cell medium made the cells younger! McFarland and Holliday described the results as “striking effects on the cell morphology (shape and structure). The cells raised in carnosine-supplemented medium looked the same as they did when they were young even over time, yet the ones raised in the regular medium got old, blotchy , irregular and broke apart into scattered islands of twisted debris.
I was kidding about that being the best news…it gets
better…to take things one step further..the scientists took the old, pooped-out
cells from the standard medium and put them into the carnosine supplemented
medium, and they reversed this process by taking the carnosine supplemented
cells and putting them in ordinary medium.
Well, the first part is not too hard to understand..the once
carnosine-supplemented cells rapidly degenerated into what would be their
normal state..but the neatest part is that the “old” cells from the normal
medium were definitely made younger again by the carnosine bath!!!!! The researchers are quoted “These cells
showed a remarkable rejuvenation, with regard to their morphology…..and finally
reached ages significantly greater than the control culture from which they
were derived.”
McFarland and Holliday subsequently repeated, confirmed and expanded on their original results. They proceeded to show that they could take regular cells, watch them age, put them in the carnosine bath, watch them grow younger and switch them back and watch them age again. They propose that carnosine is integral to cellular organization and function..optimizing longevity.
When carnosine was taken from the petri dish to the lab and studies on animals, the following findings were observed:
1) Carnosine enhanced the memory functions of the brain cells and also protected them from over stimulation by certain receptors….which in situations such as stroke can inhibit oxygen to the brain cells..leading to cellular death.
2) It inhibits the activity of MAO B (monoamine oxidase B) which is an enzyme involved in breaking down some brain messengers (such as dopamine and seratonin). MAO B activity is known to increase production of the free radical precursors hydrogen peroxide, and the enzyme becomes more active as a person gets older. Deprenyl, a drug used to treat people with Parkinson’s disease, works by inhibiting MAO B.
3) Senile cataracts in 96 seniors, who had had them for 2-21 years improved greatly by using carnosine eye drops 3-4 times per day. Positive results were seen in over 80% of the cases. Carnosine was also seen to improve general eyesight. Corneal ulcerations and erosion from viral and bacterial sources also improved greatly.
4) In the first tests, Holliday and MacFarland noticed that one of the batches of normal medium cells had become contaminated with cancer cells. It was growing rapidly. When carnosine was added to this dying population, the cell cultures became free of cancer cells! They tried it against seven different human cancers and every one showed the same result..it seems that as beneficial as carnosine is to normal cells…it was selectively toxic to human cancer cells!
5) Carnosine is a highly versatile antioxidant capable of neutralizing a large range of free radicals (superoxide, singlet oxygen, hydrogen peroxide and both peroxyl and hydroxyl radicals). Further, it has indirect antioxidant powers through chelation of pro-oxidant metals and the prevention of the destruction of the antioxidant enzyme superoxide dismutase. These qualities give a place in mercury and other heavy metal detoxification.
6) Carnosine protected cellular DNA better than any other antioxidant (Vit E, Vit C, NAC etc) under the stress of toxic levels of oxygen..in fact it was the only substance which did.
7) Carnosine also protects against the formation of Advanced Glycation Endproducts (AGE’s), proteins warped by sugar (glycated). When a protein becomes glycated, it results with the loss of that protein’s function, loss of flexibility, atherosclerosis, abnormal cellular signaling, inflammation, the complications of diabetes, and aspects of the aging process.
8) As people age, their rate of tearing down old, defective cellular proteins (proteolysis) slows down, which interferes with cellular function. Carnosine maintains proteolysis at more youthful levels in old cells. It also reacts with abnormal proteins, making it easier for the body to rid itself of them.
9) In some cases, carnosine changes gene expression in cells exposed to it, including increasing the expression of vimentin, a protein involved in maintaining the integrity and complex internal structure of the cell.
10) Carnosine enhances various aspects of immunity and protects cells against damage from a variety of toxins produced in the body as a part of normal metabolism such as the lipid peroxidation product malondialdehyde; the cancer-causing glycation product methylglyoxal; hypochlorite, a deadly substance made by cells of the immune system to kill off invading pathogens, but also toxic to the body’s own cells; formaldehyde’ and the amyloid beta-peptide, which forms the seed of the plaques associated with Alzheimer’s. Carnosine also prevents the development of amyloid into full-fledged plaques.
Dosing:
Carnosine had some short-lived popularity some years back as this information was coming out of the various research labs. The big problem was that the dosing was way under what we now knows actually works. At that time people were taking 20-50 mg a few times per day.
We now know that effectiveness starts at around 900 – 1000 mg per day. Many supplements only have 50 to 75 mg. in them..so will never give you the benefits you are looking for. At Y2K Health and Detox, we use one with 500mg per capsule and have people take 2 per day away from food.
Purchase Carnosiner Here - Y2K Health Store
For further information, you can e-mail us at y2khealthanddetox@on.aibn.com
DID YOU KNOW????
Bug Season!…. to eliminate wasps from an area, place a small jar of water nearby with a small opening in. Spread around the hole with honey and under the lid. When they go into the jar (small mason jar works well) for the honey, they become trapped!
Too many fruit flies in the kitchen?? Put out a bowl of apple cider vinegar. They go for it like a magnet and will fly into it and drown.
Laundry Day Tips:
Want to make sure a new piece of clothing doesn’t run?? Wash it for the first time in 1 gallon of water to 1 teaspoon of Epsom salts. It won’t run and will be safe to mix in the load next time.
A cheap, safe spot remover can be made using 2 parts of water to 1 part rubbing alcohol.
Spring cleaning and washing slip covers? Put them back on while still damp to prevent shrinking and also it avoids having to iron them!
E-COMMERCE – “THE” BUSINESS
OPPORTUNITY OF A LIFETIME!
What I am sharing in this part of my newsletter is, in my
opinion, one of the best business openings of our lifetimes. Many of my patients/subscribers are people
who had to give up work because of ill health.
You may have one of many reasons to want to develop your own business,
and if this is true for you, then you absolutely MUST check this out!
When I started my site, I had intended to make a mountain of information available for the public to read and self-educate themselves about health and healing. But my site was just one of “goodness-knows-how-many” health sites on the Internet.
That is when I was fortunate enough to run into Corey Rudl’s site on Internet Marketing. His course taught me about writing newsletters, e-mails, advertising techniques and tips and his “Site Promoter” software helped us sign up to the search engines in the terms each understands (and believe me they vary from one to the next…greatly). We are now accepting associates because of AssocTrac, doing E-Books with E-Book Pro, and developing the commerce part with E-Commerce Solutions. To be perfectly honest…there is not one of Corey’s products, which have not been a “God-send” to us.
To look at these little Golden Eggs of Information,
click on the link below which will take you to the page on my site with details
of each item and links to Corey’s site with explicit details. I know you will find his information
fascinating and I can personally attest to their effectiveness. Now is the time…the Internet will be THE
business centre of the future…Be There!
Warm regards,
Dr. Deb.
www.y2khealthanddetox.com/imcaffiliates.html
I am setting a new aspect to the newsletter called ‘Ask Dr. Deb”. We will be encouraging you to send your own questions as they relate to health issues whether yourself, family, children or even holistic pet care. Please send all questions to:
Each newsletter, I will try to answer one on adult health, children’s health and natural animal care. I will not be able to answer ALL questions, but as time allows, will get to as many as possible.
Thanx and enjoy the Spring!
Warmly,
Dr. Deb
