ANTIOXIDANTS-PREVENTION AGAINST AGING
BENFOTAMINE--CARAMELIZATION OF THE FLESH
© Dr. Deb Baker 2009
imperceptibly, AGE reactions create chemical handcuffs which gum
up your proteins, deactivate your enzymes, trigger unhealthy biochemical
signaling in your cells, and damage your DNA. Aging you. This is
also partially why low carbohydrate diets work well for some people
and those with neurological problems such as autism, Alzheimer's,
and even heavy metal toxicity.
recently, scientists have come to understand another pathway of AGE
formation - a distinctly biological pathway, which only occurs within
your cells because of the body's metabolism of carbohydrates.
results in a buildup within the cell of super-reactive glucose-metabolic
intermediates known as triosephosphates. And once that happens, the
excess triosephosphates attack the surrounding proteins, lipids,
and DNA, causing AGE damage from within the heart of the cell. It's
these cells are thus the most vulnerable to the complications of
diabetes and other functional disorders.
other hand, some companies are selling supplements are marketed as "AGE-inhibitors." But
while many of the herbs and other nutrients may be valuable, and
many even inhibit AGEing in a test tube, there's no evidence that
most of these "AGE-blocking" antioxidants have any effect on prevention
against AGEing in your body at the dosages used.
include thyme extract, inositol, acetyl-L-carnitine, taurine, and
a whole host of antioxidants (including n-acetyl-cysteine (NAC) and
flavonoids, such as quercetin and resveratrol).
Our Hero … in Chains!
more, TPP can exert a two-pronged AGE-inhibiting effect in the body,
because boosting TPP in cells stressed by high glucose concentrations
opens up an important biochemical "safety valve"
in the normal metabolism of blood sugar through an enzyme known as
transketolase. Activating transketolase allows the body to shunt excess
triosephosphates into a safe alternative metabolic pathway, preventing
the logjam that leads to the buildup of triosephosphates and the formation
As a result,
you get no additional AGE-battling benefit from taking preformed
thiamin pyrophosphate instead of standard thiamin. In fact, when
you take supplements based on TPP itself, studies show that thiamin
levels and biological activity are actually lower than if you take
the same amount of regular thiamin!
Benfotiamin's unique open-ringed structure makes it able to pass directly through cell membranes, readily crossing the intestinal wall and being taken straight into the cell.
is even more bioavailable than the other allithiamines, including
thiamin tetrahydrofurfuryl disulfide/TTFD. Yet Benfotiamin is actually
less toxic than conventional thiamin supplements!
started with 320 milligrams of Benfotiamin per day for the first
two weeks, followed by 120 milligrams for the rest of the trial.
Before and after the trial, the function of patients's nerve cells
were tested using nerve conduction velocity (NCV) and vibratory perception
threshold (VPT) (which tests the nerves's sensitivity by determining
the lowest level at which vibrations applied at key nerve sites are
The power of Benfotiamin to improve vibratory perception threshold and nerve conduction velocity have been confirmed in other trials. Clinical trials have also shown that Benfotiamin supports nerve function in diabetics as measured by many other methods. For instance, Benfotiamin users experience a 50% reduction in diabetic nerve pain, along with an increased ability of the nerves to detect an electrical current, respond to electrical stimulation, and regulate the heartbeat.
Benfotiamin prevents this loss of control from happening in the first
place in diabetic dogs. In another human clinical trial, a B-vitamin
combination using Benfotiamin as its thiamin source was put head-to-head
with a B-complex supplement that included a megadose of conventional
thiamin. Benfotiamin proved its effectiveness on several of these
key parameters, while the standard thiamin pill failed.
STOP CHANGE IN SENSES IN AGING
new studies have begun to document Benfotiamin's ability to shield
other tissues from AGE damage. One just-published study tested the
ability of thiamin and Benfotiamin to protect diabetic rodents' retinas
from the ravages of AGE.
nine months of diabetes, diabetic animals had suffered three times
as many acellular capillaries as were found in healthy animals. But
with the protection afforded by Benfotiamin, the number of acellular
capillaries in the supplemented diabetics was indistinguishable from
that of their normal, healthy cousins!
Dr. Paul Thornalley of the University of Essex has just completed a study designed to see if Benfotiamin will protect diabetic rodents against kidney damage. While the results have not yet been published, Dr. Thornalley has indicated that both megadose thiamin and Benfotiamin caused clear-cut reductions in the leakage of protein - with Benfotiamin showing itself to be the superior intervention.
study is now underway to see if Benfotiamin will actually improve
kidney function in diabetic animals with pre-existing kidney damage,
as it has already been shown to do in the nerves of diabetic animals
BENFOTIAMIN is available Here
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