ORTHO-GLUCOSE
Diabetes is a syndrome characterized by abnormally elevated
sugar levels in the blood. There are two types of diabetes
mellitus: type 1 or insulin-dependant diabetes and type 2,
which is non-insulin-dependant. Insulin is central to diabetes
simply because it is the hormone that regulates the metabolism
of glucose. Insulin regulates the entry of glucose in our
cells, thereby regulating blood sugar levels. The ß cells of
the pancreas produce insulin. Insulin is released when blood
glucose levels rise, as is the case after a meal. Glucose is
the main source of energy for our cells and without the action
of insulin, there is improper glucose utilization and storage,
which leads to several metabolic derangements including
elevated blood sugar levels.
The incidence of diabetes is rapidly increasing and in 2005, 7% of
the United States population had diabetes. The prevalence of the
disease increases with age.
In type 1 diabetes, the immune system is attacking the pancreas’s
insulin-producing cells. This leads to the inability to produce
adequate levels of insulin and without the presence of insulin,
blood sugar levels rise uncontrollably. Type 1 diabetes sufferers
require additional insulin to regulate their blood glucose levels.
Type 1 diabetes is typically diagnosed in childhood or early
adulthood. Unfortunately, the cause remains unclear.
Type 2 diabete usually develops in late adulthood and although
insulin production may be compromised later in the course of type 2
diabetes, the condition is primarily the result of increased insulin
resistance. Insulin resistance refers to the inability of our cells
to respond to insulin even when normal levels of insulin are
present. Once cells become insulin resistant, glucose cannot enter
cells and blood glucose levels rise. Type 2 diabetes is far more
common, comprising 90% of diabetic patients.
Type 2 diabetes is a disease that develops slowly and for which
three separate stages have been identified:
Insulin resistance has another serious consequence; not only does it
lead to elevated blood sugar levels but it also predisposes to heart
disease. Diabetics are twice as likely to suffer from cardiovascular
disease and are five times more likely to experience a heart attack.
Insulin resistance gives rise to risk factors for heart disease such
as lower HDL cholesterol levels (the beneficial cholesterol
fraction), abdominal obesity, higher triglyceride levels and
elevated low-density cholesterol (the unfavourable cholesterol
fraction). Obesity is closely related to insulin resistance and is
one of the main risk factors for the development of type 2 diabetes.
There is also a strong genetic influence on the development of type
2 diabetes with identical twins (which share the same genes) having
a 90% concordance in the occurrence of the disease.
Other frequent complications of diabetes include retinal damage,
blindness (diabetes causes 8% of blindness cases in the US),
hypertension (73% of diabetics have elevated blood pressure),
neuropathy (affecting 60-70% of diabetics), arteriosclerosis, dental
disease, increased susceptibility to infections, stroke, kidney
failure (main cause of dialysis in developed countries) and ulcer
formation, which can lead to gangrene and amputation (one amputation
every 30 seconds worldwide). In type 2 diabetes, especially earlier
in the disease process, exercise, dietary changes and weight loss
may restore insulin sensitivity and normalize blood sugar levels.
Patients that control their blood sugar levels minimize the damage
to their organs (mainly kidneys, blood vessels and eyes) and their
incidence of complications is significantly reduced and nearly
normal.
ORTHO-GLUCOSE |
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Code: 4513
Price:$42.00
Shipping Weight: 0.00 pounds
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| | 90 Capsules |
DISCUSSION: Ortho•Glucose™ is AOR’s most advanced glucose
metabolism support formula, including a range of standardized
botanicals along with trivalent chromium picolinate. Research
has supported the ability of these nutrients to potentiate
and/or mimic the glucose metabolic functions of insulin, and
to activate peroxisome proliferator-activated receptors alpha
and gamma –transcription factors which act as cellular lipid
sensors and regulators of lipid metabolism.
90 Capsules 368 mg
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SUPPLEMENT FACTS:
Serving Size: 1 Capsule
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Hops Isohumulones (from 100 mg Humulus lupulus L. extract)†
....79 mg
Cinnamon (Cinnamomum zeylanicum extract)†
.... 50 mg
Corosolic acid (from 1% Lagerstroemia speciosa extract)†
....500 mcg
Chromium (trivalent Cr picolinate)‡
....600 mcg
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Usual Dosing....1 capsule, three times per day.
Explanation of contents:
Isohumolones
Extracted from hops, these bitter compounds were added to
Ortho•Glucose™ because they improve insulin sensitivity in patients
with type 2 diabetes and in animals suffering from insulin
resistance. Isohumulones are capable of activating peroxisome
proliferator-activated receptors, which are cellular receptors with
a central role in energy metabolism. These receptors regulate both
the action of insulin and the metabolism of fat. They are the ideal
nutrient to prevent the development and advancement of type 2
diabetes and reduce the likeliness of cardiovascular complications.
Animal studies have shown that supplementation with isohumulones
reduces blood triglyceride and free fatty acid levels, normalizes
blood glucose levels and leads to weight loss. In type 2 diabetic
patients, 8-week supplementation with isohumulones resulted in
significant reductions of 6.4% in hemoglobin A1c levels and an
impressive 10.1% reduction in blood glucose levels. Systolic blood
pressure was also reduced by 7.2%.
Cinnamon
Cinnamon is a popular spice that has been known since antiquity. It
is no coincidence that cinnamon is often used for the preparation of
desserts. Indeed, laboratory work has demonstrated that cinnamon
enhances cellular glucose uptake and utilization. Animal studies
have also confirmed that supplementation with cinnamon improves the
action of insulin, increases insulin levels and prevents the
development of insulin resistance in animals fed a diet high in
sugar.
Clinical trials have revealed that the bark of this small tree is a
great choice for patients suffering from type 2 diabetes mellitus.
Cinnamon improves the cellular uptake of glucose through its
insulin-like activity. It also appears to reduce the gastric
emptying rate, which results in lower levels of blood glucose after
eating. Reported reduction of fasting plasma glucose levels varied
from 10 to 29% depending on the initial glucose levels, and patients
with poorly controlled blood glucose levels benefited even more from
supplementation with cinnamon.
As previously mentioned, diabetic patients often have abnormal blood
lipid and cholesterol levels, which predisposes them to cardiac
complications. After 40 days of cinnamon supplementation, blood
triglycerides and cholesterol levels were significantly reduced.
Cinnamon can therefore be used to avoid type 2 diabetes, decrease
blood glucose levels in diabetics and reduce the risks of common
complications associated with diabetes.
Corosolic Acid
Extracted from banana, corosolic acid delays starch digestion, has
insulin-like activity and improves glucose uptake - hence its
inclusion in Ortho•Glucose™. Animal studies showed that corosolic
acid improves glucose metabolism and reduces insulin resistance.
Corosolic acid given prior to an oral glucose tolerance test (a test
designed to measure the body’s ability to use glucose) to subjects
having various degrees of impaired glucose metabolism revealed that
corosolic acid increases insulin release and reduces blood glucose
levels.
Chromium
Chromium is an essential mineral for the metabolism of
carbohydrates. Chromium increases the sensitivity of insulin
receptors, which increases the cellular transport of glucose and
reduces blood sugar levels. Double-blinded, placebo-controlled
studies have demonstrated that chromium supplementation lowers blood
glucose levels, reduces hemoglobin A1c concentrations, and improves
cholesterol levels.
It has been established that lifestyle changes, dietary
modifications and supplementation with nutrients capable of
improving glucose metabolism are effective methods to prevent
insulin resistance and manage elevated blood glucose levels.
Ortho•Glucose contains isohumulones, cinnamon extract, corosolic
acid and chromium picolinate. These nutrients and plant extracts are
supported by clinical research in diabetic subjects. They have been
shown to reduce elevations in blood sugar levels, potentiate the
action of insulin, improve the cellular utilization of glucose and
reduce risk factors for complications associated with diabetes. They
are the ideal choice for those trying to regain normal carbohydrate
metabolism and striving to achieve normal blood glucose levels.
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