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ORTHO - BONE
Ortho•Bone is a multi-nutrient combination designed to support bone health. It features ossein microcrystalline hydroxyapatite complex (MCHC), a lyophilized extract of bovine bone, which retains the intact microcrystalline structure of whole bone. The MCHC in Ortho•Bone is derived from Australian pasture-fed, free-range livestock not subjected to routine antibiotics or rBGH. Guaranteed free of bovine spongiform encephalopathy.
For those who wish full details - See the information below the Capsule Contents.
ORTHO-BONE |
| Quantity in Basket:none
Code: 4019
Price:$65.00
Shipping Weight: 0.00 pounds
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| | 300 Capsules |
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CAPSULE CONTENTS:
Serving Size: 10 Capsules
%DRI
Ossein Microcrystalline Hydroxyapatite Complex (MCHC) 4762 mg
Calcium (from MCHC) 1000 mg
Phosphorus (from MCHC) 510 mg
Protein (from MCHC) 1514 mg
Magnesium (Monoaspartate, Ascorbate) …. 420 mg
Vitamin D3 (Cholecalciferol) ………………… 1000 IU
Menatetrenone (Vitamin K2 as MK-4) ………. 250 mcg
Boron (Citrate) …………………………….. 3 mg
Strontium (Citrate) …………………………. 5 mg
Zinc (Citrate) …………………………….. 11 mg
Manganese (Glycinate) ………………….. 2.3 mg
Copper (Citrate) ………………………. 1 mg
Silicon (Metasilicate) ……………………… 25 mg
Folic acid …………………………………. 400 mcg
Vitamin B12 ………………………………... 24 mcg
Vitamin C (Magnesium Ascorbate) ………… 90 mg
Other ingredients: lipid carrier of vitamin D3 in starch-coated matrix of gelatin and sucrose. Capsule: gelatin.
ORTHO-BONE
From being thought of as a disease affecting a few little old ladies with hunched backs, osteoporosis has leapt into the public consciousness – and with it, the importance of nutrition in maintaining bone health. Yet there remains confusion in the minds of many health-conscious people about the right dose and form of even the most well-known bone health nutrients, while the importance of other key nutrients in keeping the skeleton strong remains largely unknown. A superior nutritional supplement for bone health must be built on a foundation of ossein Microcrystalline Hydroxyapatite Complex (MCHC) as the calcium source, and fortified with well-established nutrient cofactors such as Magnesium, Zinc, Manganese, Copper, Vitamin C, and Vitamin D3, as well as critical factors like Menatetrenone (the mammalian form of vitamin K2) and Strontium, whose revolutionary effects on bone health have only emerged recently have only just been made available to North Americans wanting to take good care of their bones. Here’s a quick primer on some of the controversies – and some discoveries that are so new that you won’t even know there’s been a debate.
• Get Enough Calcium. Current “official” recommendations suggest an intake of 1000 milligrams of calcium for younger adults, and 1200 milligrams for people over the age of 50. Some evidence suggests that a still higher intake (1300-1600 milligrams) of calcium is more effective for lowering fracture risk in the elderly. But remember that these numbers are your total calcium need. The more calcium you get in your diet, the less you need from supplements.
• Get the Right Kind of Calcium. Too many health-conscious people believe that conventional calcium supplements (or conventional calcium plus vitamin D) can put an end to bone loss. They can’t. As multiple studies have documented, conventional calcium supplements – such as calcium gluconate, calcium citrate, and calcium carbonate – slow, but do not halt or reverse, menopausal bone loss, whether taken alone or with vitamin D. You simply can’t force the bones to take in more calcium, and build more bone, by taking more and more calcium: the mineral itself can only provide the raw material needed to support your existing bone mass, or to allow other factors in your skeletal health program to build up new bone.
But there is one seeming exception. Ossein microcrystalline hydroxyapatite complex (MCHC) consistently halts, or even reverses, bone loss in controlled human trials. When put head-to-head against other calcium supplemental forms, MCHC consistently trumps conventional calcium supplements. But actually, this is the exception that proves the rule, because MCHC’s bone-building powers do not lie in the calcium itself.
True MCHC is not just a form of calcium, but is a calcium-based crystalline nutrient complex, which is how the mineral is actually stored in your bones. MCHC’s unique support for the skeletal system is probably due to a combination of its intact crystalline structure, and the vibrant blend of peptides, mucopolysaccharides, and growth factors which accompany the calcium in true MCHC supplements – factors which are not present in conventional calcium supplements, in bone meal, or in pure, synthetic hydroxyapatite (also known as calcium orthophosphate). The bottom line is that the unique bone health support provided by MCHC derives from the whole supplement, and not just from its calcium content.
• Calcium Citrate-Malate for Vegetarians. Unfortunately, of course, vegetarians cannot consume MCHC because it is an animal product (although premium MCHC supplements use free-range, pasture-fed livestock from countries like New Zealand or Australia as sources for the raw materials). For vegetarians, the best calcium source is calcium citrate-malate.
Calcium citrate-malate is not the same thing as calcium citrate, or as a simple admixture of calcium citrate and calcium malate. Calcium citrate-malate is prepared in such a way that a significant number of its calcium atoms are bound to both citrate and malate molecules at once. This unique form makes calcium citrate-malate six to nine times more easily dissolved in the stomach than plain calcium citrate.
This superior solubility may be at least part of the reason for the fact that calcium citrate-malate is considerably better-absorbed than calcium citrate. And calcium citrate-malate has been used successfully in many controlled trials to support bone mass and/or to lower fracture risk. Some of these trials have involved a direct face-off between calcium citrate-malate and other forms of calcium. Such trials demonstrate that, as might be expected from its greater bioavailability, calcium citrate-malate gives better protection to the bones than other vegetarian calcium sources – although its effects are still not as impressive as those of MCHC.
• Don’t fall for the “Coral Calcium” Hype. Some companies are making wild claims about the efficacy of calcium taken from coral reefs, not just for osteoporosis but for almost every ailment under the sun. These claims are simply bogus. There is nothing magical about “coral calcium:” it is actually almost entirely calcium carbonate, with a sprinkling of some trace minerals. Not one clinical trial has ever been performed to show that “coral calcium” is better absorbed or better utilized than other conventional calcium sources. Instead, astoundingly, the claims of high bioavailability for “coral calcium” are not based on controlled studies in humans, but on the stuff’s ability to dissolve in water; and as has been shown, such a silly test bears little relationship to the ability of a living body do absorb calcium.
• Algal Calcium: Promising, but Unproven. On the other hand, there is some science associated with so-called “active absorbable algal calcium,” which is synthesized from heat-treated oyster shell and seaweed. But there have not been any large, double-blind, controlled studies to give the kind of strong evidence for the marketing claims being made for this recent arrival on the calcium market. Most of these studies have merely looked at a variety of metabolic effects of the algal calcium compound, but have not directly assessed its effects on bone. The one small study published showing increased bone mass in Japanese women using these supplements involved just twenty women taking the algal supplement. Other This is quite unlike the powerful evidence that comes from the many larger trials supporting the effectiveness of MCHC or calcium-citrate malate in supporting bone health.
In fact, the only study to be performed in Western women using this form of calcium has yet to be accepted by a scientific journal, and “was not able to detect a significant difference between the effects of these two forms of calcium on any end point studied”: the study found that neither measures of bone resorption (teardown) nor serum intact parathyroid hormone (iPTH) in women supplementing with active absorbable algal calcium were any different from users of conventional calcium citrate.
Bottom line: take your calcium in the form of MCHC if you are comfortable with animal products; choose calcium citrate-malate if you’re not.
• Rock Around the Clock. Several recent studies have suggested that when you take your calcium can make a big difference in terms of both the amount of calcium you’ll absorb, and the effects of that calcium on your bones. For starters, take your calcium with food, as doing so will increase absorption. It’s also important to spread your calcium supplements over the course of the day, which increases your total absorption of calcium and keeps parathyroid hormone (PTH) under control throughout the day. To get the best possible results, take the largest single dose of calcium later in the day, at dinner or with a late-night snack.
• Take Enough Vitamin D. Aside from improving calcium absorption, vitamin D is needed for proper muscle function, which may play a role in protecting against fractures by reducing falls. But you simply can’t rely on the sun to meet your requirements, especially in Northern climates. Even in sunny Spain, researchers have found that 80% of children have inadequate vitamin D levels in March and October. In fact, in one remarkable recent study, researchers at Creighton University were able to document that even North Americans who spend nearly all day in the sun during the summer (such as landscapers and agricultural workers) were still at a 58% risk of being too low in vitamin D to support optimal calcium metabolism by the end of the winter!
From what we now know, the old RDA of 400 IU will not protect you from vitamin D insuffciency except in the sunniest of climates. Studies show that a 400 IU vitamin D supplement is just not enough to keep serum levels of the active vitamin above the cutoff for insufficiency, and the use of 400 IU supplements have not been shown to reduce fracture rates. Even 600 IU has little effect on BMD. Instead, controlled studies show that vitamin D, together with calcium, helps to reduce the risk of fracture at a dose of at least 800 IU per day.
The best form of vitamin D is cholecalciferol (vitamin D3 – the animal-sourced form). Unfortunately, this form is only presently available from animal sources. Vegetarians will prefer to use ergocalciferol (vitamin D2) – but should understand that it just isn’t as effective as the more active D3 form.
• Take a Magnesium You Can Absorb. Magnesium is central to various aspects of bone metabolism, and borderline magnesium deficiency is surprisingly common. Unfortunately, far too many bone health formulas force you to rely on magnesium oxide as your source of this mineral, for the simple reason that it takes up less room in a capsule, and therefore requires fewer capsules to be taken to reach a standare daily dose. But compared to other sources of the mineral, magnesium oxide has extremely low bioavailability (22.8%). Additionally, magnesium oxide is an antacid, which can impair digestion and nutrient absorption. This is an especial concern in many older people, whose low stomach acid may even trigger pernicious anemia (flat-out B12 deficiency).
Magnesium citrate is certainly somewhat better, at 29.64% absorption, but it’s still far from the best magnesium you can choose. Much better absorption is available from other forms – especially fully-reacted magnesium aspartate, with a remarkable 41.7% bioavailability.
• Small Doses … Big Benefits! Just a small amount of some key nutrients can play a big role in the health of your bones. Among the most well-known are manganese, zinc, and copper, as well as other, even more commonly-neglected nutrients such as silicon, boron, and vitamin C. Methylating nutrients such as vitamin B12 and folic acid may also be important to bone health, perhaps because of the toxic effects of homocysteine on the protein fibers in bone.
More recently, Menatetrenone and Strontium have emerged as bone-building superstars. Menatetrenone is a specific form of vitamin K2, not to be confused with the common phylloquinone (vitamin K1) or even the bacterial menaquinones (which are also forms of vitamin K2). Multiple clinical trials show that megadose Menatetrenone supplements reduce fracture rates in osteoporotic women as well as Fosamax®-type drugs, without having much influence on bone mineral density; apparently, they work their magic by improving the quality of the bone itself. Strontium, the neglected bone health mineral, appears to be the first truly bone-building nutrient, as opposed to supplements like calcium and vitamin D (or even estrogen therapy or bisphosphonates), which work primarily by preventing the breakdown of old bone.
Younger, healthier people looking to support their basic bone health should consider taking these nutrients at kind of doses equivalent to what’s found in the best diets: 5 milligrams of Strontium, and a few hundred micrograms of Menatetrenone. Clinical trials to treat women with full-blown osteoporosis use much higher doses: 45 milligrams of Menatetrenone, and 600 to 700 milligrams of Strontium.
•The Phosphorus Paradox. It’s widely believed that Western diets are too rich in this mineral, and that excess phosphorus is bad for bone health. But phosphorus is an essential nutrient, which makes up more than half of the mineral content of bone and which is needed for osteoblast function. Nearly a third of older Americans don’t get the new RDA of this essential mineral. In fact, a recent study has raised concerns that, with so many people taking calcium as supplements instead of drinking milk (in which calcium and phosphorus come together as a bone-building team), folks who don’t get plenty of phosphorus from other sources may actually become deficient, because a high intake of calcium can reduce phosphorus absorption. Several recent reviews in the scientific literature have emphasized the importance of getting enough of this “black sheep” in the bone-health nutritional family.
• The Bone Health Lifestyle. Beyond targeting your intake of specific nutrients, there are a lot of important choices you can make which can spell the difference between building strong bones and slowly sinking into osteoporosis. Fortunately, each of these choices also has positive impacts on other aspects of your health, so that they are part of an overall healthy lifestyle and not a whole new checklist of health practices. Eat an “alkaline-ash” diet, rich in fruits and vegetables. But get enough protein, which is necessary for building the collagen network in which bone mineral is embedded: the optimal intake of protein to support a healthy skeletal system appears to be in the range of 1.0 to 1.5 grams per kilogram of body mass, or 0.45 to 0.68 grams of protein for each pound that you weigh. Keep active, focusing on weigh-bearing exercise. Maintain a healthy weight, quit smoking, and if you drink, do so in moderation.
The choices are yours to make. They’re simple to understand and easy to follow. And the greatest prize – your health – is yours to claim.
References:
Castelo-Branco C, Pons F, Vicente JJ, Sanjuan A, Vanrell JA. Preventing postmenopausal bone loss with ossein-hydroxyapatite compounds. Results of a two-year, prospective trial. J Reprod Med. 1999 Jul; 44(7): 601-5.
Ruegsegger P, Keller A, Dambacher MA. Comparison of the treatment effects of ossein-hydroxyapatite compound and calcium carbonate in osteoporotic females. Osteoporos Int. 1995 Jan; 5(1): 30-4.
Stepan JJ, Mohan S, Jennings JC, Wergedal JE, Taylor AK, Baylink DJ. Quantitation of growth factors in ossein-mineral-compound. Life Sci. 1991; 49(13): PL79-84.
Stellon A, Davies A, Webb A, Williams R. Microcrystalline hydroxyapatite compound in prevention of bone loss in corticosteroid-treated patients with chronic active hepatitis. Postgrad Med J.1985 Sep; 61(719): 791-6.
Epstein O, Kato Y, Dick R, Sherlock S. Vitamin D, hydroxyapatite, and calcium gluconate in treatment of cortical bone thinning in postmenopausal women with primary biliary cirrhosis. Am J Clin Nutr 1982 Sep; 36(3): 426-30.
Durance RA, Parsons V, Atkins CJ, Hamilton EB, Davies C. A trial of calcium supplements (Ossopan) and ashed bone. Clin Trials J. 1973 Nov; 10(3): 67-73.
Ilich JZ, Kerstetter JE. Nutrition in bone health revisited: a story beyond calcium. J Am Coll Nutr. 2000 Nov-Dec; 19(6):715-37.
Marie PJ, Ammann P, Boivin G, Rey C. Mechanisms of action and therapeutic potential of strontium in bone. Calcif Tissue Int. 2001 Sep; 69(3): 121-9.
Zittermann A. Effects of vitamin K on calcium and bone metabolism. Curr Opin Clin Nutr Metab Care. 2001 Nov; 4(6): 483-7.
AOR guarantees that no ingredients not listed on the label have been added to the product. Contains no wheat, gluten, corn, nuts, dairy, soy, eggs, fish, or shellfish.
Suggested Use:
Take up to ten capsules daily, dividing the dose among meals to facilitate maximum absorption, taking the largest single dose with the last meal or snack of the day, or as directed by a qualified health consultant.
Main Applications
As reported by literature:
•Excellent source of calcium and other nutrients.
•Bone health.
Source
MCHC: lyophilized, defatted bone tissue from free-range, pasture-fed Australian bovine livestock not subjected to routine antibiotics or rBGH. Guaranteed free of bovine spongiform encephalopathy.
Pregnancy / Nursing
Safe.
Cautions:
•Persons taking anticoagulant (“blood thinning”) medications such as warfarin (Coumadin®) must not take this supplement.
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