OLIVE LEAF EXTRACT
Olea europea
The olive leaf (Olea europea) has been widely used by the Greeks and Romans since antiquity. In the early 1990s olive leaf extract was introduced as dietary supplement for its antiviral and antibacterial activities.
Calcium elenolate (CE) a hydrolysed synthetic product of oleuropein, was extensively studied by the pharmaceutical giant Upjohn Co. in the late 60s. CE was shown to have profound antiviral activities.
However, in-vivo CE was found to quickly bind to plasma proteins, negating its activity. The research was abandoned.
Chemistry
The pharmacologically active constituents in olive leaves are secoridoids, such as: oleuropein, oleuroside, ligstroside. Other ingredients include flavonoids, apigenin, caffeic acids and triterpenes. Oleuropein, a bitter glucoside found in highest concentrations in the leaves, has been well researched.
OLIVE LEAF EXTRACT (CAPSULES) |
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Code: 1010
Price:$29.00
Shipping Weight: 0.00 pounds
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| | 60 capsules |
Pharmacological properties / Clinical applications:
Antihypertensive. Oleuropein possesses a vasodilator effect. Moreover, a recent study has found that the aqueous extract of olive leaves inhibited Angiotensin converting enzyme (ACE), an enzyme that converts angiotensin I to angiotensin II. Angiotensin II is a potent vasoconstrictor. Antithrombosis. The phenolic compound 3,4-di-hydrophenyl ethanol inhibited aggregation of platelet and production of thromboxane A2 (a stimulator of platelet aggregation with vasoconstrictor activity).
Prevention of development of atherosclerotic lesions. The secoridoid and phenolic compounds were found to protect vascular endothelium cells from damage.
Antioxidant activity. Caffeic acid and oleuropein were found to inhibit iron toxicity in rat hepatocytes by their antioxidant activity through the scavenging of superoxide radical.
Hypoglycemic effect. Oleuropein has a hypoglycemic effect possibly due to potentiation of glucose-induced insulin release and/or increased peripheral glucose uptake.
Antimicrobial Activity
1.) Antibacterial. Oleuropein has been shown to inhibit growth and the production of enterotoxin B by Staphylococcus. Oleuropein also inhibits the growth of Bacillus cereus, E. coli, pseudomar, Bacillus subtilis, etc.
2.) Antiviral. Olive leaf extract (calcium elenolate) eliminates the viruses by interfering with certain amino acid production processes. The interference stops the virus from shedding, budding, or assembling at the cell membrane. Laboratory tests suggest that the compound has the ability to penetrate infected host cells and irreversibly inhibit viral replication. Oleuropein possesses antiviral activity against a number of viruses including parainfluenza 3, herpes, influenza A, polio 1,2, and 3, etc.
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